Toward TB elimination: critical issues for research, diagnosis and treatment

NAIDS (NIH, USA) and the Harvard Medical School Center for Global Health Delivery-Dubai convened a group of scientists and stakeholders in 2017 to address knowledge gaps that affect our ability to rapidly find and treat individuals infected with M. tuberculosis who are most likely to progress to active disease. The priority areas for research, diagnosis and treatment of TB infection that emerged from the meeting were in two sections: 1. Defining the spectrum between M. tuberculosis infection and clinically apparent disease and identifying genetic and immunological markers associated with progression to disease; and 2. Optimising treatment for infection with M. tuberculosis.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ. Moving toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med 2019;199(5):564-571. doi: 10.1164/rccm.201806-1053PP.